Prilosec OTC® Safety Record and Use 

Prilosec OTC was the first proton pump inhibitor (PPI) for the treatment of frequent heartburn available over-the-counter. Since becoming available without a prescription, Prilosec OTC has safely and effectively fought frequent heartburn for more than 24 million consumers. And that number keeps growing.

The safety record of omeprazole magnesium—the active ingredient in Prilosec OTC—was demonstrated in 13 OTC clinical trials.¹

As with any drug, you’ll want to stop and ask a doctor if you experience any of the warnings as listed on the Prilosec OTC package label.

Stop use and ask a doctor if:

  • Your heartburn continues or worsens
  • You need to take this product for more than 14 days
  • You need to take more than one course of treatment every four months

Before you begin to use Prilosec OTC, ask a doctor if you have:

  • Had heartburn for more than three months. This may be a sign of a more serious condition.
  • Heartburn with lightheadedness, sweating, or dizziness
  • Chest or shoulder discomfort with shortness of breath; sweating; an uncomfortable sensation spreading to arms, neck, or shoulders; or lightheadedness
  • Frequent chest discomfort
  • Frequent wheezing, particularly with heartburn
  • Unexplained weight loss
  • Nausea or vomiting
  • Stomach discomfort

Read this important information on drug interactions with Prilosec OTC.

¹ Data on file. Procter & Gamble.
P&G calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel in the US market for Prilosec OTC for the period 8/31/03 through 12/24/11.

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