Clinically proven to block heartburn for 24 hours.*1

With one Prilosec OTC pill a day, you can block frequent heartburn symptoms before they strike for a full 24 hours of heartburn relief. That way you can power on with your day—and rest at night—without concern that your frequent heartburn will flare up. That’s because Prilosec OTC fights heartburn day and night by shutting down many of the acid pumps in your stomach. It can be the all-day, all-night heartburn protection you need.*

Available in 14-, 28-, and 42-pill packages.

1Allgood LD et al. Comparison of Prilosec OTC (omeprazole magnesium 20.6 mg) to placebo for 14 days in the treatment of frequent heartburn. J Clin Pharm Ther 2005; 30 (2): 105-12

Ratings And Reviews

This area allows consumers like you to express their own opinions and comments. Prilosec OTC does not represent or warrant the accuracy of any statements or product claims made here, nor endorses any opinions expressed within this section.

No Star
Five Star
4.69/5 (378)
  • Value:
  • Quality:
97% Recommended

No Star
Five Star


Works even after eating spicy or rich foods. No heartburn after one tablet lasting 24 hours.

Yes, I recommend this product!

Originally posted on US

*Your Location:
Portland, OR
No Star
Five Star

The packaging

Please sell these in a bottle. The bubble wrap is too hard for my arthritic thumbs to open. I love the product though!

Yes, I recommend this product!


PrilosecOTC The Prilosec OTC Team 03/18/2019

We appreciate your feedback, and we definitely want to make sure that you're able to get the relief you're looking for easily. Rest assured, we're passing this along to our Packaging department so we hear you. If you ever have any questions or concerns, please give us a call at (800) 289-9181.